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PEPFAR/Tanzania (PEPFAR/T) has an unprecedented and unique opportunity to utilize multiple updated national data sources to formulate a robust Country Operational Plan 2023 (COP23). COP23 planning was informed by preliminary unweighted key results from the Tanzania HIV Impact Survey (THIS) 2022-2023, Bio-Behavioral Survey 2022 (BBS 2022), 2022 Tanzania Demographic Health Survey, Malaria Indicator Survey (2022 TDHS-MIS), and 2022 Tanzania Population and Housing Census (2022 Census). With PEPFAR’s new Five-year Strategy: Fulfilling America’s Promise to End the HIV/AIDS Pandemic by 2030 as a framework, the new demographic, epidemiologic, and health surveillance data enabled PEPFAR/T to shape COP23 strategies to fill programmatic gaps and address health with the goal of reaching the Joint United Nations Programme on HIV/AIDS (UNAIDS) 95-95-95 targets within two years.