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Eswatini has made striking progress in controlling the HIV/AIDS epidemic, led by the Government of the Kingdom of Eswatini (GKoE), and in partnership with the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), the Global Fund to Fight AIDS, Tuberculosis and Malaria, other donors, as well as with civil society organizations (CSOs). While Eswatini has the world’s highest HIV prevalence rate, with 24.9% of adults living with HIV, tremendous forward movement has been measured and attained. The recently completed 2021 Eswatini Population-based HIV Impact Assessment survey, locally known as “SHIMS3”, demonstrated sustained progress towards the ambitious UNAIDS 95 95-95 targets well before the global 2025 benchmark.