Dapivirine Vaginal Ring Early Market Access Vehicle (EMAV)

8 October 2024

In response to the voices of adolescent girls and women who need more HIV prevention choices, The Global Fund (GF) and the Children Investment Fund Foundation (CIFF) have partnered to make dapivirine vaginal rings available in GF-supported countries through an early market access vehicle.

Objective: Facilitate immediate access to one-month ring to accelerate availability for users, expand PrEP choice, and catalyze impact while less expensive rings come to market with an approximate 60% drop in price/month.

Mechanism Summary:

Eligible Applicants: Country entities with HIV product procurement and supply chain responsibilities who may or may not be GF principal recipients or sub recipients in countries which received an HIV allocation for GC7. Endorsement by National Ministry of Health or other government agency responsible for the HIV response is required. Product registration is not required if import waiver can be obtained.

Available Volumes: 2,400 (min.) and 24,000 (max.) one-month rings, per country, for use across 2025 and 2026. Available rings will be allocated on a first-come first-served basis to requests which meet the criteria below. CIFF will fund up to 150k rings in total. This page will be updated as volumes are allocated.

Deadline: Requests are accepted on a rolling basis after launch October 30.

Monitoring and Evaluation: Quarterly reporting to CIFF and leveraging reporting of GF and PEPFAR, when applicable.

Featured Resources

External Link

Adolescent Girls and Young Women Overcoming Adherence Challenges with Vaginal and Oral PrEP Use: A longitudinal qualitative study from a crossover trial in South Africa, Uganda, and Zimbabwe

This article from AIDS and Behavior explores South African, Ugandan, and Zimbabwean adolescent girls and young women’s experiences in a crossover trial of two HIV prevention products: daily oral PrEP and a monthly dapivirine vaginal ring.

Spreadsheet

Access Workbook for Cabotegravir for PrEP, Dapivirine Vaginal Ring, and Lenacapavir for PrEP

This workbook, compiled by the Global Fund, contains key access information relating to cabotegravir (CAB) for PrEP, the dapivirine vaginal ring (DVR), and lenacapavir (LEN) for PrEP for all lower and middle income countries, including eligibility for Global Fund support, PEPFAR support status, regulatory status of CAB for PrEP and the DVR, access to non-profit…

PrEP Ring Instructional Video

The PrEP Ring is a long-acting vaginal ring that a woman can use to reduce the risk of HIV transmission during vaginal sex. Women urgently need options for HIV prevention, so that they can choose that best meets their needs and circumstances. Please click on the video link(s) below to see How to Use the…

External Link

We Choose: Adolescent girls and young women’s choice for an HIV prevention product in a cross-over randomized clinical trial conducted in South Africa, Uganda, and Zimbabwe

This article from PLOS One describes decision-making and product choice amongst adolescent girls and young women in South Africa, Uganda, and Zimbabwe when given a choice between oral PrEP and the dapivirine vaginal ring as part of the REACH crossover study.

Document

HIV Self-Testing and PrEP: Opportunities for scale-up

This brief addresses common misconceptions about the use of HIV self-testing (HIVST) for PrEP initiation and continuation while highlighting the opportunities that HIVST can provide in order to support further scale-up of this important self-care option.

External Link

PrEP Method Switching: Will it Yield Greater Coverage of HIV Protection? Applying Lessons Learned from Family Planning to Guide Future Research in the Context of PrEP Choice

This review from Current HIV/AIDS Reports draws parallels between HIV prevention and family planning by summarizing how method choice and product switching affected contraceptive coverage globally, synthesizes what is known about PrEP product switching, and outlines evidence gaps to help guide future research on PrEP switching in the context of choice.

Spreadsheet

2024 Q2 Global PrEP Tracker

AVAC’s Global PrEP Tracker offers two views on PrEP uptake around the world. Visit data.prepwatch.org for a dynamic map-based tool to explore trends in oral PrEP use globally as countries introduce and scale up PrEP programs. For insights on the full scope of PrEP use around the world, the PrEP Tracker as a spreadsheet offers…

Document

Pre-Exposure Prophylaxis and Adolescent Girls and Young Women in Eastern and Southern Africa: The latest insights

Eastern and southern Africa (ESA) is the world’s most heavily HIV-impacted region, with adolescent girls and young women (AGYW) disproportionately affected. To support the scale-up of PrEP amongst AGYW in ESA, in September 2021 UNICEF and partners released the implementation brief “Improving the Quality of Pre-Exposure Prophylaxis Implementation for Adolescent Girls and Young Women in…

External Link

Self-reported Removal and Expulsion of the Dapivirine Vaginal Ring: Qualitative reports from female ring users and their male partners in the Ring Study (IPM 027)

This article from BMC Public Health explores participants’ and their male partners’ discussions on accidental/purposeful vaginal ring removals during The Ring Study (IPM-027 clinical trial of the one month dapvirine vaginal ring).

Document

MOSAIC (Maximizing Options to Advance Informed Choice for HIV Prevention)

Short introduction to MOSAIC, a project working across multiple countries to implement user-centered research and research translation efforts to identify, understand, and remove barriers to new product introduction, access, and use; coordinate and provide technical assistance to global, national, and subnational stakeholders to expedite product launch and scale-up; and strengthen the capacity of a wide…