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Oral PrEP, PrEP Ring, and CAB PrEP Template Guidelines (English)

25 November 2024

The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) pre-exposure prophylaxis (PrEP) recommendations and guidance, including those for tenofovir disoproxil fumarate (TDF)-based oral PrEP, the monthly dapivirine vaginal ring (“PrEP ring” or “the ring”), and injectable cabotegravir (CAB PrEP). The document includes prompts for national-level consideration during the guideline adaptation process. This template is also available in French and Spanish

Topic(s): Normative Guidance/Policies

Product(s): Cabotegravir, Dapivirine Vaginal Ring, Event-Driven PrEP, Oral PrEP, TDF/xTC

Format(s): Form/Template, Report

Source(s): MOSAIC

Type: Document

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Featured Resources

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Safety and Drug Quantification of the Dapivirine Vaginal Ring and Oral Pre-Exposure Prophylaxis in Breastfeeding Mother–Infant Pairs (MTN-043): A phase 3B, open-label, randomised trial

This article from The Lancet HIV discusses the results of the Microbicide Trials Network (MTN)-043 trial, which assessed the safety of use of the dapivirine vaginal ring during breastfeeding amongst participants in Malawi, South Africa, Uganda, and Zimbabwe.

MTN-020 ASPIRE

Archived from the MTN website before it was taken down. Archived MTN ASPIRE news page available here. Primary Objectives Determine the effectiveness of dapivirine (25 mg) administered in a silicone elastomer matrix vaginal ring (VR), when inserted once every 4 weeks, in preventing HIV-1 infection among healthy sexually active HIV-uninfected women Assess the safety of…
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Interest in Injectable and Oral PrEP for HIV Prevention Among Women and Men Who Inject Drugs

This article from Journal of Addiction Medicine examines interests and concerns around use of oral and injectable PrEP amongst people who inject drugs in the United States.
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PrEP Booklet of Frequently Asked Questions (FAQs): A Peer Outreach Worker Tool

This tool was developed to be used by peer outreach workers, peer educators, and other community-based health providers to help provide comprehensive information about pre-exposure prophylaxis (PrEP) to key population peers.
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Determinants of Continuation on HIV Pre-exposure Propylaxis among Female Sex Workers at a Referral Hospital in Uganda: A mixed methods study using COM-B model

This article from BMC Public Health describes the results of a study to evaluate PrEP continuation among female sex workers and explore potential determinants of PrEP adherence within a public referral hospital in urban Uganda.
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Oral PrEP Factsheet

This adaptable factsheet can be used by program implementers to raise awareness about oral pre-exposure prophylaxis (PrEP). It highlights tips for using oral PrEP, side effects, and dosing regimens for different groups of people.
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Long-Acting PrEP for Key Populations: Considerations for Implementation

This document is intended for program implementers, advocates, policymakers, and other stakeholders who influence the rollout of long-acting options for pre-exposure prophylaxis (PrEP). It highlights some of the considerations for long-acting PrEP implementation for key population individuals.
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PEP Template Guidelines (English)

The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) post-exposure prophylaxis (PEP) recommendations and guidance. The document includes prompts for national-level consideration during the guideline adaptation process.
External Link

Understanding the Drivers of CAB PrEP Uptake and Use among Women in sub-Saharan Africa to Build Demand for New PrEP Methods

This article from Current HIV/AIDS Reports reviews facilitators and barriers to use of injectable cabotegravir (CAB) for PrEP by women in sub-Saharan Africa.
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Global Acute HIV Infection Algorithm Job Aids for Providers

This tool can assist providers in assessing acute HIV infection (AHI) in clients using oral PrEP, PrEP ring, and CAB PrEP by offering guidance through three steps: HIV testing, recent exposure to HIV assessment, and AHI assessment. Providers are encouraged to use clinical judgement and defer to national guidance as needed.