Resource Library

USAID Microbicide Product Introduction Initiative (MPii)

USAID Microbicide Product Introduction Initiative (MPii) The US Agency for International Development’s (USAID) Office of HIV/AIDS is supported five interconnected projects on ARV-based HIV prevention product introduction and access, the Microbicide Product Introduction Initiative (MPii) agreements, that run from 2015-2020. MPii Tools & Resources: Available here. OPTIONS – Optimizing Prevention Technology Introduction On Schedule Who:…

Microbicide Trials Network-042 – DELIVER Study

Microbicide Trials Network-042/DELIVER is a Phase IIIb open-label study designed to evaluate the safety and acceptability of the monthly dapivirine vaginal ring and oral PrEP in pregnant women.

Research

Microbicide Trials Network-043 – B-PROTECTED Study

Microbicide Trials Network-043, or B-PROTECTED, is a Phase IIIb open-label study that evaluated the safety and acceptability of the monthly dapivirine ring and daily oral PrEP in women who are breastfeeding, a time of heightened vulnerability for acquiring HIV.

Research

CHARISMA Mobile: Developing a digital resource for empowerment counseling, community health clinic model for agency in relationships and safer microbicide adherence

CHARISMA is a PEPFAR- and USAID-funded empowerment counseling intervention designed to help women use oral pre-exposure prophylaxis and other antiretroviral-based HIV prevention technologies safely and effectively by addressing dynamics of their relationships with male partners, including exposure to intimate partner violence. The intervention, designed to be delivered by lay counselors, is being adapted into a…

Research, Service Delivery

A Randomized Trial of Safety, Acceptability and Adherence of Three Rectal Microbicide Placebo Formulations Among Young Sexual and Gender Minorities Who Engage in Receptive Anal Intercourse (MTN-035)

This journal article from PLOS ONE was a trial seeking to evaluate the safety, acceptability, and adherence to three placebo modalities (insert, suppository, enema) prior to receptive anal intercourse (RAI).

Research

PrEP That Booty: The latest on rectal microbicide research for the back door

Thursday, June 29 at 9:00 AM–10:30AM ET Most of what we hear about regarding the HIV prevention pipeline is about long-acting, longer-acting, and even longer-acting products that deliver drug throughout the body and require a trained clinician to deliver. However, these attributes are not desirable to many folks, and communities want a range of choices.…

Monitoring & Evaluation, Research

ART Considerations for Individuals with Recent PrEP Use

This brief provides an overview of key findings from modeling the impact of drug resistance with PrEP, conducted by the Global Evaluation of Microbicide Sensitivity (GEMS) project. It is intended to support policymakers as they develop the most appropriate first-line ART treatment recommendations during PrEP rollout.

Service Delivery

Dapivirine Ring Modeling Literature Review

A 2017 report on the results of a review of studies on the dapivirine vaginal ring (the PrEP Ring) and microbicide modelling.

Financing & Costing, Research

MTN-023/IPM 030 “iMatter”

Microbicide Trials Network-023/International Partnership for Microbicides 030 was a Phase 2a trial to assess safety of the dapivirine vaginal ring in HIV-uninfected adolescent females

Research, Service Delivery

Results of open-label study of a vaginal ring for HIV prevention suggest women are interested in and willing to use it

This article from the Microbicide Trials Network shares the results of an open-label study of a vaginal ring for HIV prevention

Community/Advocacy, Demand Creation/Marketing, Research

MATRIX Project Overview

This factsheet provides an overview of USAID’s Microbicide Research and Development to Advance HIV Prevention Technologies through Responsive Innovations and Excellence (MATRIX) project.

Community/Advocacy, Research