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HIVR4P 2024 Knowledge Toolkit

3 March 2025

The HIVR4P 2024 Knowledge Toolkit highlights important scientific advancements and innovative research across key thematic areas presented at the HIVR4P 2024 conference. Thematic areas include the PURPOSE 2 trial of long-acting lenacapavir for PrEP, data on the three-month dapivirine vaginal ring, and early evidence on offering a choice of PrEP methods.

Topic(s): Research

Product(s): Dapivirine Vaginal Ring, Lenacapavir

Format(s): Toolkit

Source(s): IAS

Type: External Link

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Featured Resources

External Link

Safety and Drug Quantification of the Dapivirine Vaginal Ring and Oral Pre-Exposure Prophylaxis in Breastfeeding Mother–Infant Pairs (MTN-043): A phase 3B, open-label, randomised trial

This article from The Lancet HIV discusses the results of the Microbicide Trials Network (MTN)-043 trial, which assessed the safety of use of the dapivirine vaginal ring during breastfeeding amongst participants in Malawi, South Africa, Uganda, and Zimbabwe.

MTN-020 ASPIRE

Archived from the MTN website before it was taken down. Archived MTN ASPIRE news page available here. Primary Objectives Determine the effectiveness of dapivirine (25 mg) administered in a silicone elastomer matrix vaginal ring (VR), when inserted once every 4 weeks, in preventing HIV-1 infection among healthy sexually active HIV-uninfected women Assess the safety of…
External Link

Interest in Injectable and Oral PrEP for HIV Prevention Among Women and Men Who Inject Drugs

This article from Journal of Addiction Medicine examines interests and concerns around use of oral and injectable PrEP amongst people who inject drugs in the United States.
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PrEP Booklet of Frequently Asked Questions (FAQs): A Peer Outreach Worker Tool

This tool was developed to be used by peer outreach workers, peer educators, and other community-based health providers to help provide comprehensive information about pre-exposure prophylaxis (PrEP) to key population peers.
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Long-Acting PrEP for Key Populations: Considerations for Implementation

This document is intended for program implementers, advocates, policymakers, and other stakeholders who influence the rollout of long-acting options for pre-exposure prophylaxis (PrEP). It highlights some of the considerations for long-acting PrEP implementation for key population individuals.
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Global Acute HIV Infection Algorithm Job Aids for Providers

This tool can assist providers in assessing acute HIV infection (AHI) in clients using oral PrEP, PrEP ring, and CAB PrEP by offering guidance through three steps: HIV testing, recent exposure to HIV assessment, and AHI assessment. Providers are encouraged to use clinical judgement and defer to national guidance as needed.
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Gears of Lenacapavir for PrEP Rollout

This report provides a framework for accelerated and equitable introduction of injectable lenacapavir (LEN) for PrEP, including outlining priority actions for different stakeholder groups.
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Daily Oral PrEP, PrEP Ring, and CAB PrEP Template Guidelines (Spanish)

The intent of this document is to provide adaptable guidelines to support the development and adoption of national guidelines that align with World Health Organization (WHO) pre-exposure prophylaxis (PrEP) recommendations and guidance, including those for tenofovir disoproxil fumarate (TDF)-based oral PrEP, the monthly dapivirine vaginal ring (“PrEP ring” or “the ring”), and injectable cabotegravir (CAB…
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HIV Prevention User Journey Tool

The HIV Prevention Journey Tool was developed to support adolescent girls and young women to explore methods that would align with their lifestyle, needs and personal preferences; and support healthcare providers to provide informed counseling based on client needs. The digital tool, which has been optimized for use on mobile devices, can be accessed here.…
External Link

Twice-Yearly Lenacapavir for HIV Prevention in Men and Gender-Diverse Persons

This article from the New England Journal of Medicine describes the results of PURPOSE 2, the Phase III clinical trial for injectable lenacapavir for PrEP, carried out amongst gay and bisexual men who have sex with men, trans men, trans women, and gender non binary individuals in Argentina, Brazil, Mexico, Peru, South Africa, Thailand, and…