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The US President’s Emergency Plan for AIDS Relief (PEPFAR) worked closely with the Government of Rwanda (GOR), including senior leadership at the Ministry of Health (MOH), stakeholders, and representatives from civil society organizations to develop Rwanda’s Country Operational Plan (COP) for 2023 (FY23/24). This year’s COP has been set for 2 fiscal year targets; the second year will follow the review of year 1 achievements. PEPFAR’s 5-year strategic plan to end HIV as a global health threat by 2030 was used as direction in the development of this year’s country operation plan.