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PEPFAR-Ethiopia (PEPFAR-E) has progressed well towards reaching 95-95-95 targets despite facing a COVID-19 epidemic, armed conflict, the worst drought in 40 years, multiple infectious disease outbreaks, widespread food insecurity, and other humanitarian crises across the country. Country operational plan (COP) 23 provides an opportunity to anchor PEPFAR-E programming in the PEPFAR 5X3 strategy by collaborating with the MOH, civil society organizations (CSOs), and multilateral organizations to progress toward reaching the 95-95-95 targets by 2025.