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Country Overview:
South Africa

Global PrEP Tracker
Last Updated: 19 November 2024

Drug Registration Status

Approved
Not
Approved
Under
Review
Data not
available
Gilead's Truvada (TDF/xTC*) Registration
Approved 2015 2015
Generic versions of TDF/xTC* for prevention
Approved N/A N/A
ViiV's Apretude (CAB for PrEP) Registration
Approved 2022 2022
IPM's Dapivirine Vaginal Ring Registration
Approved 2022 2022
Oral F/TAF (Descovy) Registration
Not Approved
* TDF/xTC refers to tenofovir disoproxil fumarate (TDF) and either emtricitabine (FTC) or lamivudine (3TC)

Research, Demonstration and Implementation

Oral PrEP

34 Completed Projects

Dapivirine Vaginal Ring

7 Planned/Ongoing Projects

Injectable PrEP

24 Planned/Ongoing Projects

Policy Frameworks

South African Guidelines for the Provision of Pre-exposure Prophylaxis (PrEP) to Persons at Substantial Risk of HIV Infection, 2020

National Strategic Plan for HIV, TB and STIs, 2017-2022

National Sex Worker HIV Plan, 2016-2019

National Policy on HIV PrEP and Test and Treat, 2016

Est. Cumulative
Initiations:

Total PrEP: 1,342,154

Oral PrEP: 1,337,133

Dapivirine Vaginal Ring: 966

Injectable PrEP: 4,055

Where To Access PrEP in South Africa:

Get PrEP

HIV Care Now

Featured Resources

Document

South Africa Strategic Direction Summary, 2023

Through the President’s Emergency Plan for AIDS Relief (PEPFAR) Country Operational Plan 2023 (COP23), the United States (US) government will support the Government of South Africa (GoSA) toward the shared goal of ending HIV as a public health threat by 2030. PEPFAR South Africa (PEPFARSA) is centering COP23 on the GoSA’s vision and strategy for…
Presentation

HIV Post-Exposure Prophylaxis (PEP) Training

This resource, produced by the South Africa National Department of Health, is a comprehensive training on post-exposure prophylaxis (PEP) provision for health care providers. Additional Resources: Clinical Algorithm for Initiation of HIV Post Exposure Prophylaxis (PEP) for HIV Prevention PEP Counseling Job Aid PEP FactSheet
Document

South Africa PrEP Implementation Study Mapping Analysis

This analysis aims to investigate which questions will/will not be addressed by the current slate of ongoing or planned implementation science to inform decisions about investments in additional research (if needed) and provide an understanding of when insights across key questions will become available to help inform the rollout planning for the new PrEP methods…
Document

Stakeholder Conversations to Inform Delivery of New HIV Prevention Methods in South Africa

A readout of conversations with local stakeholders about the dapivirine vaginal ring, looking to gain insight on implementation considerations from providers and potential end-users.
Presentation

Breaking the Cycle of HIV Transmission: A Human Centered Design Approach to Reach Adolescent Girls and Young Women

Many Adolescent Girls and Young Women (AGYW) at high risk for HIV have difficulties sustaining prevention behaviors. To address this challenge, Upstream and Final Mile used Human Centered Design (HCD) methodologies to undertake behavioral research and design and pilot an intervention. Over 3,000 AGYW and 135 influencers (such as male partners and community health workers)…
Document

Dapivirine Ring Early Introduction Considerations — South Africa Analysis

The OPTIONS Consortium conducted secondary research and interviews with key stakeholders in several countries to understand questions about the ring that could inform demonstration and processes for introducing new biomedical HIV prevention products. South Africa was prioritized for analysis due to the state of the HIV epidemic in the country and experience with ring trials.…
Document

Monitoring & Evaluation Plan for the National Strategic Plan on HIV, TB, & STIs, 2017-22

South Africa’s M&E Plan builds on achievements in the fight against HIV/AIDS from the past and continues to lay the groundwork for collecting vital information for this effort into the future. It informs how to improve and scale up service delivery and implementing evidence-based interventions. This Plan also outlines the key indicators, their definitions, data…
Document

Oral PrEP Youth Dialogues South Africa

The OPTIONS Consortium, in close collaboration with the South African Department of Health, developed the creative concept ‘We Are The Generation That Will End HIV’ and applied it to all information, education and communication (IEC) material. The creative concept aimed to generate demand for oral PrEP as an additional and acceptable HIV prevention method. Short…
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