Research Impact
Implications of the PEPFAR Stop Work Order
The CATALYST Study
The USAID-funded implementation study, implemented by FHI 360 and partners and scheduled to run through 2028, has been terminated early.
What was the project focused on?
- The project, via local partners, was offering a choice of injectable CAB, the dapivirine vaginal ring, or oral PrEP to 11,000 adolescent girls and young women
- All study sites were collecting data on choice among the three options, with the exception of sites in Kenya, which were to commence CAB in February
What is happening now?
- Participants are being exited from the study and will no longer be able to access CAB or DVR at study sites; some participants are being transitioned onto oral PrEP where available
- FHI 360 is working with product developers to see if remaining supply of CAB and DVR can be transferred to MoH; the fact that product has been labelled for study use makes this challenging